Effects of Coenzyme Q10 on Blood Biochemistry in Rats
نویسنده
چکیده
CoenzymeQ10 (CoQ10) is used as a food supplement and as an ethical drug because of its antioxidant functions and key role in mitochondrial bioenergetics. In this study, the effects of CoQ10 on blood biochemistry and malondialdehyde (MDA) levels in rats were investigated. Ten male Wistar rats ages ranging between 7 and 8 weeks were used. All animals were kept under the same condition and were given free access to standard rat chow and tap water ad libitum. The CoQ10 treated rats received daily administrations of 10 mg/kg body weight of CoQ10 by oral gavage for 10 days. Control rat groups were treated in an identical fashion with oil. The measurement of biochemical parameters; sera glucose, triglyceride, cholesterol, total protein, albumin, ALT, ALP, BUN, creatinin, calcium, magnesium, phosphorus, iron and plasma malondialdehyde levels were analysed. In CoQ10 treated rats, decreased levels of ALP and increased levels of P in serum were found compared to levels in control rats. The other parameters analyzed in the serum were not significantly different between control and CoQ10 treated rats at dose of 10 mg/kg BW for 10 days. No major effects on the parameters investigated in this study were observed following coenzyme Q10 treatment.
منابع مشابه
Effects of Coenzyme Q10 on Hemoglobin A1C, Serum Urea and Creatinine in Alloxan-Induced Type 1 Diabetic Rats
Coenzyme Q 10 is a natural antioxidant and free radicals scavenger. In the present study, we examined effect of coenzyme Q 10 on hemoglobin A 1C , serum urea and creatinine in alloxan-induced Type 1 diabetic rats. Thirty Sprage-Dawley male rats were divided into three groups randomly; group one as control, group two diabetic untreatment, and group three treatments with coenzyme Q ...
متن کاملBeneficial Effects of Coenzyme Q10 in Streptozotocin-Induced Type I Diabetic Rats
The present investigation was undertaken to study the benefical effects of Coenzyme Q10 in streptozotocin (STZ)-induced type I diabetic rats. STZ-diabetes produced a significant increase in fasting glucose levels that was associated with decrease in serum insulin levels. STZ also produced hypercholesterolemia, hypertriglyceredemia, increase in lipid peroxidation and decrease in high density lip...
متن کاملThe Effect of coenzyme Q10 supplementation on oxidative stress status and insulin resistance in diabetic rats
Background and Aim: Coenzyme Q10 is an antioxidant it is now used in diseases associated with oxidative stress. Given the importance of oxidative stress in the complications of diabetes, this study aimed to investigate the effect of CoQ10 supplementation on the status of oxidative stress and insulin resistance was performed in diabetic rats. Materials and Methods: 18 Sprague-Dawley male rats w...
متن کاملThe effect of coenzyme Q10 on oxidative stress parameters and testicular tissue damage in rats following monosodium glutamate induced excitatory intoxication
Background: Monosodium glutamate (MSG) is known as a food flavor enhancer that can adversely affect the male reproductive system. The present study was investigated the protective effect of coenzyme Q10 (Co-Q10) against MSG-induced oxidative stress and histopathological changes in rat testicular tissue. Materials and methods: In this experimental study, 40 adult male Wistar rats were randomly ...
متن کاملEffects of Coenzyme Q10 and Vitamin C on Growth Performance and Blood Components in Broiler Chickens under Heat Stress
This experiment was carried out to study the effects of Coenzyme Q10 (CoQ10) and vitamin C (VC) on growth performance and blood biochemistry in broiler chickens under heat stress conditions. One of three levels of CoQ10 (0, 20, and 40 mg/kg of diet) and one of two levels of VC (0 and 250 mg/kg of diet) were supplemented to diets of chicks (from 1-42 d of age) in a 3 × 2 factorial arrangement. E...
متن کاملEffect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners
Background: Heavy exercise cause muscle damage associated with production of inflammatory agents. The purpose of present study was to determine the effect of acute and 14-day Coenzyme Q10 supplementation on inflammatory, blood lactate and muscle damage in male middle-distance runners. Methods : Eighteen male middle-distance runners in a randomized and quasi experimental study were allocated...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2009